Beneficial metabolic phenotypes caused by loss-of-function APOC3 mutations.
نویسنده
چکیده
1. Gagné SE, Larson MG, Pimstone SN et al. A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study. Clin Genet 1999: 55 (6): 450–454. 2. Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations inPCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006: 354 (12): 1264–1272. 3. Nierman MC, Rip J, Kuivenhoven JA et al. Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance. Metabolism 2005: 54 (11): 1499–1503.
منابع مشابه
Loss-of-function mutations in APOC3 and risk of ischemic vascular disease.
BACKGROUND High plasma levels of nonfasting triglycerides are associated with an increased risk of ischemic cardiovascular disease. Whether lifelong low levels of nonfasting triglycerides owing to mutations in the gene encoding apolipoprotein C3 (APOC3) are associated with a reduced risk of ischemic cardiovascular disease in the general population is unknown. METHODS Using data from 75,725 pa...
متن کاملAPOC3 may not be a predictor of risk of ischemic vascular disease in the Chinese population
The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition of APOC3 significantly reduces plasma levels of apolipoprotein C3 and triglycerides. Recently, the TG and HDL Working Group and Jørgensen et al. reported that loss-of-function mutations in APOC3 are associated with decreased triglyceride levels and a reduced risk of ischemi...
متن کاملCURRENTOPINION Therapy and clinical trials
DOI:10.1097/MOL.0000000000000151 The link between triglyceride levels and cardiovascular disease was first described several decades ago. Several high-quality observational studies and clinical trials [1,2 & ,3–5,6 && ,7,8] have since demonstrated that elevated levels of triglycerides are associated with an increased risk of cardiovascular disease, myocardial infarction, stroke and all-cause mo...
متن کاملa predictor of risk of ischemic APOC 3 vascular disease in the Chinese population
The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition of significantly APOC3 reduces plasma levels of apolipoprotein C3 and triglycerides. Recently, the TG and HDL Working Group and Jørgensen reported that loss-of-function et al. mutations in are associated with decreased triglyceride levels and a APOC3 reduced risk of ischemi...
متن کاملmay not be a predictor of risk of ischemic vascular APOC 3 disease in the Chinese population
The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition of significantly APOC3 reduces plasma levels of apolipoprotein C3 and triglycerides. Recently, the TG and HDL Working Group and Jørgensen reported that loss-of-function et al. mutations in are associated with decreased triglyceride levels and a APOC3 reduced risk of ischemi...
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عنوان ژورنال:
- Clinical genetics
دوره 87 1 شماره
صفحات -
تاریخ انتشار 2015